Service Provider - Durviz SL

IVO

Service Provider

Laboratory Overview

The Laboratory is located at the The Fundacion Instituto Valenciano
de Oncología (IVO), a cancer center dedicated to fight against
cancer in the fields of prevention, diagnosis, treatment,
research and teaching.

Provide a personalized medicine

Through genetic analyses for early detection, prevention (hereditary cancer), prediction
of response for targeted therapies and immunotherapies, and prognosis.

High quality results

Use cutting edge technology (NGS-based) to provide high quality results in a competitive timeframe.

ISO15189-Accredited: carries out all activities to the highest quality standar

Translational research projects

Participate in the design of preclinical and translational research projects, also in the genomic characterization of biological samples from patients included in clinical trial.

Features and Benefits

HTG EdgeSeq technology

Let HTG IVO Service Provider be an extension
of your organization. Take advantage
of the benefits of HTG EdgeSeq
technology without the up-front
capital expense.

High-quality data leveraging

Molecular profiling expertise: highly trained and dedicated staff delivering high-quality
data leveraging the advantages
of the HTG EdgeSeq technology.

Receive a customized report

Focused on turnaround times: receive a customized report on tens to thousands of biomarkers to meet your timelines.

Without the capital investments

Deferred investment cost: all the advantages of targeted next-generation sequencing (NGS)-based
results without the capital investments,
training, and labor costs.

Quality Control

Bioinformatic Analysis: all reports include
standard level analysis (Process read
counts and parsing FASTQ files.
Quality Control).

Assays Offered by IVO Laboratory

RUO

HTG EdgeSeq miRNA Whole Transcriptome Assay

2,083 miRNA human transcripts (analysis using a variety os samples).

Develop profiles of human miRNA transcripts and evaluate gene regulation.

RUO

HTG EdgeSeq Oncology Biomarker Panel

2,560 oncology-related genes – drug targets / signaling pathways.

Comprehensive characterization of genes associated with tumor biology.

RUO

HTG EdgeSeq Precision Immuno – Oncoloy Panel

1.392 inmuno-oncology related genes.

Characterize tumor microenvironment and immune response.

RUO

HTG Transcriptome Panel

19.398 genes: profiling almost the entire transcriptome in a variety of samples.

Comprehensive Profiling of the Human mRNA Transcriptome.

RUO

HTG EdgeSeq Immune Response Panel

2.002 immune pathway related genes.

Analize genes associated with immune response to infection and autoimmune disease.

RUO

HTG EdgeSeq DLBCL Assay

ABC / GCB subtyping and profiling 92 lymphoma genes plus drugs targets.

Characterize diffuse large B-cell lymphoma subtypes.

RUO

HTG EdgeSeq Pan B-Cell Lymphoma Panel

298 B-Cell Lymphoma relevant genes and DLBCL COO via DAC classifier.

Characterize indolent and aggressive lymphoma subtypes.

RUO

HTG EdgeSeq mouse mRNA Tumor Response

1.659 murine immuno-oncology related mRNAs.

Analize genes associated with Oncology, Immunology and Inflamation.

Bioinformatic Analysis Offered

by IVO Laboratory

Standart	Process read counts and parsing FASTQ files. Quality control
Level 1	Exploratory analysis. Principal components analysis. Multidimensional scaling. Differential expression analysis by genes. Differential expression analysis by pathway.
Level 2	Analysis Level 1 plus: Linear regression. Random forest regression
Level 3	Analysis Level 1 and 2, plus: Pathway analysis and visualization (In development). GO analysis (In development)
Level 4	Custom Bioinformatic Assays

Sample Requirements

IVO Service Provider laboratory accepts a wide variety
of clinical samples for testing including formalin-fixed,
paraffin-embedded (FFPE) tissue, plasma/serum, PAXgene,
extracted RNA from tissues and cells. Sample types andamounts
are specific to each assay and customer project.

For more information contact IVO Service Provider at: durviz@durviz.com

Partner with HTG

IVO Service Provider laboratory supports biomarker research and companion diagnostic development using HTG’s
extraction-free technology and growing portfolio of profiling assays.

The HTG EdgeSeq system has a number of key advantages, including
multiplexing from tens to thousands of biomarkers in a single sample;
very low sample input requirements; simple, extraction-free sample
preparation; automated workflow; and simplified data output.

IVO Service Provider laboratory is a powerful resource that
can deliver gene expression profiling results for researchers,
laboratory staff, and biomarker leads pursuing discovery, translational
medicine, diagnostic and retrospective oncology applications.

For more information contact IVO Service Provider laboratory at: +34 961366107 or send an email to: durviz@durviz.com

Durviz SL
Parque Tecnológico Valencia,
Leonardo da Vinci 10
46980 Valencia, Spain
Phone: +34 931616107
Email: durviz@durviz.com

HTHIVO-SP180317

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